Who and Why does one need liver transplant?
When life with liver disease becomes miserable, expected survival is limited for months and patient’s life style is restricted, liver transplant is indicated. Liver transplant extends survival and improves quality of life style as a result of which person can lead active and productive life. All patients referred for transplant do not need transplant, some patients are too high risk for transplant surgery and some patients are too early for transplant surgery.
Which disease need liver transplant?
There are numerous diseases of liver which may need transplant. By and large progressive and irreversible disease process leading to end stage liver disease need transplant. All the diseases are treated with drugs first and transplant is the last option. Transplant is needed when drugs fail to act; and expectancy and quality of life is predicted to be short.
Following are the diseases which may require transplant:
- 1) Viral Hepatitis induced cirrhosis –
- a. Hepatitis B
- b. Hepatitis C
- 2) Alcohol induced cirrhosis
- 3) Inborn errors of metabolism
- a. Hemochromatosis (increased producing and deposition of iron in body mainly liver)
- b. α1 – Antitrypsin deficiency (absence of chemical, important for maintaining function of lungs and liver)
- c. Wilson’s disease (increased production and deposition of copper in the body mainly liver)
- d. Glycogen storage disease type I/ III
- 4) Cholestatic disease
- a. Biliary atresia (birth defect leading to failure of development of bile draining tubes)
- b. Primary biliary cirrhosis (obstruction to flow of bile primarily in the liver)
- c. Familial cholestasis Byler’s syndrome, anteriohepatic dysplasia (congenital stasis of bile inside liver)
- d. Cystic fibrosis, Insipissated bile syndrome leading to cirrhosis.
- e. Primary sclerosing cholangitis (scarring, narrowing and inflammation of biliary tree)
- f. Secondary biliary cirrhosis (irreversible liver damage due to obstruction to bile tubes from outside the liver)
- 5) Acute fulminant hepatic failure
- a. Drug induced –paracetamol poisoning
- b. Fulminant Hepatitis A or E (severe form of liver injury which results in failure of liver)
- 6) Vascular
Budd Chiari Syndrome (blocked of hepatic veins)
- 7) Congenital abnormalities
- a. Urea cycle enzyme deficiency
- b. Homozygous hypercholesterolemia
- c. Primary hyperoxaluria type
- d. Familial amyloidotic polyneuropathy
- 8) Developmental abnormalities
- a. Polycystic liver disease (formations of multiple fluid filled cavities inside liver)
- b. Caroli’s disease (birth defect of biliary radicles, dilatations inside liver leading to failure to drain bile)
- 9) Tumors
- a. Hepatocellular carcinoma (cancer of liver)
- b. Metastasis to liver (cancer spread from other organs)
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India Liver Transplant provides information on liver transplant in India and abroad, cost of liver transplant, success rate of liver transplant, liver transplant in China, liver transplant in Delhi, about pros and cons of liver surgery, treatment for common liver diseases, cirrhosis, jaundice, hepatitis, liver donor, risks to liver donor's life, cadaveric liver transplant, liver cancer treatment, liver transplant medicines, post liver transplant life, care, precautions and sucess rate, acute liver failure by India's most experienced liver transplant coordinator Jyotsna Verma who worked with pioneers of Liver transplant surgery in India, Dr. A. S. Soin, Dr. Samiran Nundy, Dr. Subash Gupta, Dr. Vivek Vij, Dr. Rahul Kakodkar, Dr. Vinay Kumaran, Dr. Mohammed Rela, Dr. Anand Ramamurthy, and worked with best liver transplant team at Liver Transplant Unit Sir Ganga Ram Hospital(SGRH), Institute of Liver Transplantation and Regenerative Medicines, Medanta - The Medicity, Gurgaon and Fortis Hospitals, NOIDA and has been to ILBS (Institute of Liver and Biliary Sciences).
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[Liver Transplant in India]: Jyotsna Verma ( Liver Transplant Consultant(India) )
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